DEVELOPMENT OF A NOVEL FLUORESCENCE ASSAY BASED ON THE USE OF THE THROMBIN-BINDING APTAMER FOR THE DETECTION OF O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE ACTIVITY

Human O6-alkylguanine-DNA alkyltransferase (hAGT) is a DNA repair protein that reverses the effects of alkylating agents by removing DNA adducts from the O6 position of guanine.Here, we developed a real-time fluorescence hAGT activity assay bible flask that is based on the detection of conformational changes of the thrombin-binding aptamer (TBA).Th

Background and aim: Diabetic retinopathy(DR) is one of the most common complications of long-standing diabetes mellitus(DM).Early detection of essie cause and reflect this complication in the preclinical stages by Visual Evoked Potential (VEP) may help formulate management strategies to preserve Vision.With this background in mind, we conducted a c

Machine learning models (e.g., neural networks) achieve high accuracy in wind power forecasting, but they are usually regarded as black boxes that lack interpretability.To address this issue, the paper proposes a glass-box model that combines high accuracy with transparency for wind power forecasting.Specifically, the core is to sum up the feature

In this article, the electronic and optical properties of bulk TiC and its narrow nanowires were investigated using Quantum-Espresso/PWSCF computational package in the framework of density functional theory.According to the results, this compound showed a metallic behavior in the bulk structure, but the small diameters of the nanowires against the